Good question. It was not noticeable for me. But now I'm curious if it is significantly slower. What suspect is that the JSON parsing is what's causes you the delay. IPC serializes your message and deserializes it in the main process. Plus, Axios also deserializes the response to your request. Three JSON parse operations can be expensive. In my case, this not a problem and worth the security and ease of use.
I did find this StackOverflow question about IPC having high latency. The suggested solution was to use your a server (started in the main process) and using WebSockets or other network communication to send and receive data. I did try this using ExpressJS, and it worked, but I didn't feel comfortable shipping a server with my app. I can post the code if you're interested, but there are probably some tutorials online.
Info:
https://stackoverflow.com/questions/54590888/faster-alternatives-for-electrons-ipc-modulehttp://expressjs.com/